A COMMENTARY ON MORPHOLOGICAL AND QUANTITATIVE ASPECTS OF MICROPARTICLE TRANSLOC

2020-03-26 16:24:28

data analysis particle CARR Of

责任者: HODGES, GM;CARR, EA;HAZZARD, RA;OREILLY, C;CARR, KE 单位: QUEENS UNIV BELFAST,CTR MED BIOL,SCH BIOMED SCI,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND. 来源出处: JOURNAL OF DRUG TARGETING, v 3 1995, p 57- 60 摘要: It is now generally accepted that particulates in the nano-range ( 1 mu m) and this is discussed in relation to the variety of experimental designs present in the literature. Emphasis is placed on the relative contributions of quantitative bulk tissue analysis with respect to qualitative and quantitative morphological analysis. The discussion is extended to observations on factors influencing the particle translocation process including variation in particle uptake in relation to intestinal region and time post-dose adminstration based on data for uptake of similar to 2 mu m latex particles by rat Peyers patch tissue. Although a significant body of data now identifies the intestinal processus of particle translocation it is underllined that discrepencies may arise as a consequence of different analytical approaches and that this is an issue to be addressed for valid comparisons of data. 关键词: CONFOCAL MICROSCOPY; GI MUCOSA; MICROPARTICLES; NANOPARTICLES