Magic ferritin: A novel chemotherapeutic encapsulation bullet

2019-09-24 05:59:03

pH drug HCl doxorubicin apoferritin

责任者: Simsek, Ece;Akif Kilic, Mehmet 单位: Department of Biology, Faculty of Science, Akdeniz University, Antalya, Turkey 来源出处: Journal of Magnetism and Magnetic Materials,2005,293(1):509-513 摘要: The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin-HCl gives rise to a solution containing five doxorubicin-HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity. © 2005 Published by Elsevier B.V. 关键词: Drug products;Chemotherapy;Dissociation;Hydrochloric acid;Drug dosage;pH effects;Encapsulation;Cells;Physiology;Apoferritin;Doxorubicin;Ferritin;Nano-delivery systems;Liposomes