Photo-thermal ablation of cancer by using photosensitive nanoparticles

2019-09-11 22:05:45

thermal cancer nanoparticles photon ablation

责任者: Watanabe, Toshiyuki;Tsubouchi, Mari;Totani, Kenro;Kamada, Kenji;Iwase, Youichiro;Kondo, Kouichi;Kataoka, Kazunori 单位: Tokyo Univ. of Agri. and Tech., Koganei-shi, Tokyo 184-8588, Japan 来源出处: Nonlinear Optics Quantum Optics,2005,34(1-4 SPEC ISS):271-274 摘要: Two-photon initiated thermal ablation of cancer was investigated. Polymer nanoparticles consisting of two-photon chromophore were synthesized by using poly(ethylene glycol)-poly(b-benzyl-L-aspartate) block copolymer. Mono dispersed nanoparticles having 70 nm diameters were obtained. In the case of MPPBT nanoparticle, quantum yield decreases and two-photon absorption cross section increases compared with that of MPPBT solution which is preferable for photo thermal ablation of cancer. Uptake of nanoparticles into Hela cell was confirmed by fluorescent imaging. PDA assay reveals that two-photon thermal ablation by using nanoparticles is effective for cancer therapy. © 2005 Old City Publishing, Inc. 关键词: Laser ablation;Tumors;Nanostructured materials;Elementary particles;Polymers;Chromophores;Synthesis (chemical);Block copolymers;Medical imaging;Two-photon absorption cross section;Quantum yield;Nanoparticles;Photothermal ablation