Modified Poly(ε-caprolactone)s and Their Use for Drug-Encapsulating Nano

2019-08-18 12:23:55

poly oxide copolymers caprolactone epsilon

责任者: Iojoiu, Cristina;Hamaide, Thierry;Harabagiu, Valeria;Simionescu, Bogdan C. 单位: Petru Poni Inst. Macromolec. Chem., 6600 Iasi, Romania 来源出处: Journal of Polymer Science, Part A: Polymer Chemistry,2004,42(3):689-700 摘要: Poly(ε-caprolactone) (PCL)-polydimethylsiloxane diblock and triblock co-polymers and poly(ε-caprolactone-co-4-ethylcaprolactone) random copolymers were prepared through the homogeneously catalyzed coordination anionic polymerization of ε-caprolactone (CL) and the copolymerization of CL with 4-ethyl-e-caprolactone (EtCL) in the presence of hydroxy-terminated polysiloxanes or allyl alcohol as chain-transfer agents, respectively. Polysiloxane precursors with hydroxypropyl or hydroxyethyl propyl ether end groups were obtained by the hydrosilation of the appropriate unsaturated alcohol with monofunctional or difunctional hydro-terminated polysiloxanes of different molecular weights. As proven by differential scanning calorimetry analysis, the presence of siloxane blocks and EtCL units determined the diminished copolymer crystal-unity, which was shown by the reduced melting temperatures and enthalpy of fusion with respect to those of pure PCL. Both types of copolymers were found to form, in the presence of a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) emulsifier, monodisperse and stable nanoparticles able to encapsulate different types of bioactive compounds (Vitamin E and indomethacin). © 2003 Wiley Periodicals, Inc. 关键词: Biopolymers;Nanostructured materials;Chemical modification;Drug dosage;Copolymers;Copolymerization;Silicones;Melting;Alcohols;Molecular weight;Crystallization;Anionic polymerization;Biodegradation;Solvents;Homopolymerization;Substitution reactions;Synthesis (chemical);Polycaprolactones;Polydimethylsiloxanes;Random copolymers